GLP-1 Was Found Inside Arthritic Joints. Here's What That Means for Your Knee.
/In 2026, researchers in Denmark found GLP-1 — the same hormone mimicked by Ozempic and Wegovy — sitting inside the synovial fluid of arthritic joints, along with the enzyme that regulates it. It was the first time this hormone had been documented inside the knee. Patients on these medications are reporting real pain relief, backed by the STEP 9 trial in the New England Journal of Medicine. But those same patients also lost nearly 14% of their body weight — and every pound translates to several pounds of force through the joint. Whether the relief comes from the drug acting on the joint or from the weight coming off is still being worked out. At HealthFit in Pasadena, Dr. Jason Han treats knee arthritis through the Source-Cause-Stack — hands-on care, targeted loading, and regenerative therapy with EMTT, focused shockwave, and radial pressure wave from Day 1 — because waiting for a magic shot isn't a plan. Your knee is sending you a message. The source is the tissue. The cause is upstream. Treat both, together, from the start.
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